The main mechanism of action of NSAIDs is the inhibition of the enzyme cyclooxygenase (COX). Cyclooxygenase is required to convert arachidonic acid into thromboxanes, prostaglandins, and prostacyclins. The body releases these substances in response to illness and injury.
Lornoxicam reduces pain, fever, swelling, and inflammation

Short term symptomatic treatment of acute mild to moderate pain in adults
Symptomatic treatment of pain and inflammation in osteoarthritis in adults
Symptomatic treatment of pain and inflammation in rheumatoid arthritis in adults

The usual dose for adults is 8 to 16 mg, divided into two or three doses per day. Do not take more than 16 mg a day.
The dose for patients with arthritis is 12 mg, divided into two or three doses per day. Do not take more than 16 mg a day.
If you have a liver or kidney impairment, do not take more than 12 mg (taken twice or three times a day) of this medicine.
Lornoxicam tablets must be swallowed with sufficient amounts of liquid.
Do not take Lornoxicam with a meal, as food can reduce the effectiveness of Lornoxicam.
Lornoxicam is not recommended for children and adolescents below 18 years old, due to lack of data.
Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
If you take more than you should, talk to a doctor or go to the hospital straight away.
If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose.
Do not take a double dose (two doses at the same time) to make up for the forgotten dose.

If you get any of the following side effects, stop taking this medicine and tell your doctor immediately, or contact the emergency department at your nearest hospital:

Shortness of breath, chest pains, or ankle swelling appear or get worse
Severe or continuous stomach pain or your stools become black
Yellowing of the skin and eyes (jaundice) – these are signs of liver problems
An allergic reaction - which can include skin problems such as ulcers or blistering, or swelling of the face, lips, tongue, or throat which may cause difficulty in breathing
Fever, blistering eruption, or inflammation especially on hands and feet or in the mouth area (Stevens-Johnson syndrome); exceptionally, serious infections of the skin in case of varicella (chickenpox).

If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Massage: A lot of people find relief from gentle massage, and some hospice agencies have volunteers who are trained in massage therapy.
Physical therapy
Gel packs.

You should avoid using Lornoxicam if you are taking other NSAIDs such as acetylsalicylic acid (for instance, aspirin), ibuprofen, and COX-2 inhibitors.
Lornoxicam may interfere with other medicines. Be particularly careful if you are taking any of the following:

Cimetidine, used in the treatment of heartburn and peptic ulcers
Anticoagulants, such as warfarin, heparin, or phenprocoumon, are used to prevent the formation of blood clots
Corticosteroids
Methotrexate, used in the treatment of cancer and immunological diseases
Lithium
Immunosuppressive agents, such as cyclosporine or tacrolimus
Heart medicines, such as digoxin, ACE-inhibitors, beta-adrenergic blockers
Diuretics
Quinolone antibiotics (e.g. levofloxacin, ofloxacin)
Anti-platelet agents (e.g. clopidogrel), medicines used to prevent heart attacks and strokes
SSRI (Selective Serotonin Reuptake Inhibitors), used in the treatment of depression
Sulphonylureas, for instance, glibenclamide, used in the management of diabetes
Inducers and inhibitors of CYP2C9-isoenzymes (such as the antibiotic rifampicin or the antifungal medicine fluconazole), as might have an effect on the way in which your body breaks down the drug
Angiotensin II receptor blocker used to treat high blood pressure, kidney damage due to diabetes, and congestive heart failure
Pemetrexed is used to treat some forms of lung cancer.

Store below 25°c
Don’t refrigerate
Keep this medicine out of the sight and reach of children.
Store in the original package to protect from moisture.
Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month.

Xefo, Anti-Inflammatory, 8 Mg - 20 Tablets

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