Product Name

Zestril 20 Mg, Reduce Blood Pressure, Prevent Hypertension Complication - 28 Tablets

Scientific Name

Lisinopril 20 Mg Tablets

Category Of Zestril 20 Mg Tablets

Anti-Hypertensive Drugs

Mechanism Of Action Of Lisinopril

Lisinopril belongs to Angiotensin-converting-enzyme inhibitors which are a class of medication used primarily for the treatment of high blood pressure and heart failure. They work by causing relaxation of blood vessels as well as a decrease in blood volume, which leads to lower blood pressure and decreased oxygen demand from the heart.
In addition, Lisinopril blocks the conversion of angiotensin I to angiotensin II and prevents the degradation of vasodilator prostaglandins, thereby inhibiting systemic vasoconstriction, regulated by angiotensin II, and promoting systemic vasodilation.

Therapeutic Indications Of Zestril 20 Mg Tablets

To treat high blood pressure (hypertension): High blood pressure is a common condition in which the long-term force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease.
To treat heart failure (when the heart is not strong enough to work correctly)
If you have recently had a heart attack (myocardial infarction)
To treat kidney problems caused by Type II diabetes in people with high blood pressure.

Method Of Administration Of Zestril 20 Mg Tablets

Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
Swallow the tablet with a drink of water.
Try to take your tablets at the same time each day. It does not matter if you take it before or after food.
Keep taking Lisinopril for as long as your doctor tells you to, it is a long-term treatment.
For high blood pressure: the recommended starting dose is 10 mg once a day. The usual long-term dose is 20 mg once a day.
For heart failure: the recommended starting dose is 2.5 mg once a day. The long-term dose is 5 to 35 mg once a day.
After a heart attack: the recommended starting dose is 5 mg within 24 hours of your attack and 5 mg one day later. The usual long-term dose is 10 mg once a day.
For kidney problems caused by diabetes: the recommended dose is either 10 mg or 20 mg once a day. If you are elderly, have kidney problems, or are taking diuretic medicines your doctor may give you a lower dose than the usual dose.
This medicine is not recommended for children under 6 years or in any children with severe kidney problems.
The doctor will work out the correct dose for your child. The dose depends on the child’s body weight.
For children who weigh between 20 kg and 50 kg, the recommended starting dose is 2.5 mg once a day.
For children who weigh more than 50 kg, the recommended starting dose is 5 mg once a day.
Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
If you take more than you should, talk to a doctor or go to the hospital straight away.
If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose.
Do not take a double dose (two doses at the same time) to make up for the forgotten dose.

Undesirable Side Effects Of Zestril 20 Mg Tablets

Headache.
Feeling dizzy or light-headed, especially if you stand up quickly.
Diarrhea.
A dry cough that does not go away.
Being sick (vomiting).
Kidney problems (shown in a blood test).
Uncommon side effects:
Mood changes.
Change of color in your fingers or toes (pale blue followed by redness) or numbness or tingling in your fingers or toes.
Changes in the way things taste.
Feeling sleepy.
Spinning feeling (vertigo).
Having difficulty sleeping.
Stroke.
Fast heartbeat.
Runny nose.
Feeling sick (nausea).
Stomach pain or indigestion.
Skin rash or itching.
Being unable to get an erection (impotence).
Feeling tired or feeling weak (loss of strength).
A very big drop in blood pressure may happen in people with the following conditions:
coronary heart disease; narrowing of the aorta (a heart artery), kidney artery, or heart valves; an increase in the thickness of the heart muscle. If this happens to you, you may feel dizzy or light-headed, especially if you stand up quickly.
Changes in blood tests show how well your liver and kidneys are working.
Heart attack

Pregnancy & Breastfeeding Precautions While Taking Zestril 20 Mg Tablets

If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Non-Pharmacological Treatments & Advice To Reduce Blood Pressure

To measure blood pressure correctly:

Don’t eat or drink anything 30 minutes before you take your blood pressure.
Empty your bladder before your reading.
Sit in a comfortable chair with your back supported for at least 5 minutes before your reading.
Put both feet flat on the ground and keep your legs uncrossed.
Rest your arm with the cuff on a table at chest height.
Make sure the blood pressure cuff is snug but not too tight. The cuff should be against your bare skin, not over clothing.
Do not talk while your blood pressure is being measured.

You will also find the following Non-Pharmacological treatments effective in blood pressure reduction:

Lose extra pounds and watch your waistline
Exercise regularly
Eat a healthy diet
Reduce sodium in your diet
Quit smoking
Reduce caffeine
Reduce your stress
Monitor your blood pressure at home using for example Beurer, Blood Pressure Monitor or Omron Blood Pressure Measuring Device
See your doctor regularly

Warnings & Special Precautions while Taking Zestril 20 Mg Tablets

Talk to your doctor or pharmacist before taking lisinopril if you:

have a narrowing (stenosis) of the aorta (an artery in your heart) or a narrowing of the heart valves (mitral valves).
have a narrowing (stenosis) of the kidney artery.
have an increase in the thickness of the heart muscle (known as hypertrophic cardiomyopathy).
have problems with your blood vessels (collagen vascular disease).
have low blood pressure. You may notice this as feeling dizzy or light-headed, especially when standing up.
have kidney problems or you are having kidney dialysis.
have liver problems.
have diabetes.
are taking any of the following medicines used to treat high blood pressure: an angiotensin II receptor blocker (ARBs), aliskiren
have recently had diarrhea or vomiting (being sick).
have high levels of cholesterol and you are having a treatment called ‘LDL apheresis’.
are of black origin as lisinopril may be less effective. You may also more readily get the side effect ‘angioedema’ (a severe allergic reaction).
are taking any of the following medicines, the risk of angioedema is increased: temsirolimus, sirolimus, everolimus, vildagliptin.

Tell your doctor or pharmacist if you are taking any of the following medicines:

Other medicines to help lower your blood pressure.
An angiotensin II receptor blocker (ARB) or aliskiren.
Water tablets (diuretic medicines).
Beta-blocker medicines, such as atenolol and propranolol.
Nitrate medicines (for heart problems).
Non-steroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and arthritis.
Aspirin (Acetylsalicylic acid), if you are taking more than 3 grams each day.
Medicines for depression and mental problems, including lithium.
Potassium supplements (including salt substitutes), potassium-sparing diuretics, and other medicines that can increase the amount of potassium in your blood (e.g. trimethoprim and co-trimoxazole for infections caused by bacteria; ciclosporin, an immunosuppressant medicine used to prevent organ transplant rejection; and heparin, a medicine used to thin blood to prevent clots).
Insulin or medicines that you take by mouth for diabetes.
Medicines used to treat asthma.
Medicines to treat nose or sinus congestion or other cold remedies (including those you can buy in the pharmacy).
Medicines to suppress the body’s immune response (Immunosuppressants).
Allopurinol (for gout).
Procainamide (for heartbeat problems).
Medicines that contain gold, such as sodium aurothiomalate, may be given to you as an injection

Storage Conditions Of Zestril 20 Mg Tablets

Store below 25°c
Don’t refrigerate
Keep this medicine out of the sight and reach of children.
Store in the original package to protect from moisture.
Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month.

Normal Range

Normal: Blood pressure numbers of less than 120/80 mm Hg
Elevated: is when readings consistently range from 120-129 systolic and less than 80 mm Hg diastolic.
Hypertension Stage 1: is when blood pressure consistently ranges from 130-139 systolic or 80-89 mm Hg diastolic.
Hypertension Stage 2: is when blood pressure consistently ranges at 140/90 mm Hg or higher.
Hypertensive crisis: This stage of high blood pressure requires medical attention. If your blood pressure readings suddenly exceed 180/120 mm Hg, wait five minutes and then test your blood pressure again. If your readings are still unusually high, contact your doctor immediately. You could be experiencing a hypertensive crisis.

For More Information About Lisinopril

Ask your physician or pharmacist
SFDA website at Information About Lisinopril
Visit Medscape at Information About Lisinopril
Visit Drugbank at Information About Lisinopril
Visit Drugs.com at Information About Lisinopril

Zestril 20 Mg, For High Blood Pressure - 28 Tablets

Zestril 20 Mg, For High Blood Pressure - 28 Tablets

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